Beneficial effects of naringenin and morin on interleukin-5 and reactive oxygen species production in BALB/c mice with ovalbumin-induced asthma
Peng Qi, Wei Chunhua, Dianbo Kou
Abstract
P13/Akt or ERK/JNK signalling pathways in EL-4 cells, demonstrating the involvement of HO-1 expression in inhibiting asthmatic inflammation. The increased inflammatory cells in the BALF were substantially decreased by both naringenin and morin, followed by inhibition in the elevated Th-2 cytokines levels. The TNF-α protein levels in an allergic asthma mouse model were significantly reduced by suppressing Akt phosphorylation and eosinophil formation. Recent findings confirmed that naringenin and morin possess the potential to control asthma-related immune responses through antioxidant and anti-inflammatory properties, indicating potential therapeutic agents or functional foods.
Topics & Concepts
MorinNaringeninOvalbuminNFATChemistryAllergic inflammationBronchoalveolar lavageProtein kinase BImmunologyReactive oxygen speciesInflammationViability assayIonomycinPharmacologyMedicineAntioxidantApoptosisImmune systemInternal medicineIntracellularBiochemistryFlavonoidLungTranscription factorPathologyGeneAsthma and respiratory diseasesIL-33, ST2, and ILC PathwaysGenomics, phytochemicals, and oxidative stress