Taming the reactivity of alkyl azides by intramolecular hydrogen bonding: site-selective conjugation of unhindered diazides
Koshiro Maegawa, Hiroki Tanimoto, Seiji Onishi, Takenori Tomohiro, Tsumoru Morimoto, Kiyomi Kakiuchi
Abstract
The intramolecular hydrogen bonding in the α-azido secondary acetamides (α-AzSAs) enabled site-selective integration onto the diazide modular hubs even without steric hindrance.
Topics & Concepts
ChemistryIntramolecular forceSteric effectsAlkylReactivity (psychology)Hydrogen bondCombinatorial chemistryOrganic chemistryMoleculeMedicineAlternative medicinePathologyClick Chemistry and ApplicationsSynthesis and Catalytic ReactionsChemical Synthesis and Analysis