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Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial

Sivagurunathan Sutharsan, Sivagurunathan Sutharsan, Edward F McKone, Damian G Downey, Jamie Duckers, Gordon MacGregor, Elizabeth Tullis, Eva Van Braeckel, Claire E Wainwright, Danie Watson, Neil Ahluwalia, Bote G Bruinsma, Christopher Harris, Anna P Lam, Yiyue Lou, Samuel M Moskowitz, Simon Tian, Jason Yuan, David Waltz, Marcus A Mall, Paul Aurora, Stijn Verhulst, Danie Watson, Michael Lorenz, Jobst Roehmel, Wolfgang Gleiber, Susanne Naehrig, Florian Stehling, Sivagurunathan Sutharsan, Sivagurunathan Sutharsan, Silke van Koningsbruggen-Rietschel, Rainald Fischer, Damian Downey, Charles Haworth, Jamie Duckers, Julian Legg, Peter Barry, Rebecca Thursfield, Simon James Doe, Tom Hilliard, Gordon MacGregor, Edward F Nash, Nicholas John Withers, Daniel Peckham, Helen Louise Barr, Timothy Lee, Robert Gray, Francois Vermeulen, Eva Van Braeckel, Eef Vanderhelst, Philip J Robinson, Claire E Wainwright, Daniel J Smith, Siobhain A Mulrennan, Barry S Clements, Peter Wark

2021The Lancet Respiratory Medicine141 citationsDOI

Topics & Concepts

IvacaftorMedicineCystic fibrosisInternal medicineClinical trialPhases of clinical researchRandomized controlled trialMutationMEDLINEOncologyCystic Fibrosis Research AdvancesDelphi Technique in ResearchAsthma and respiratory diseases
Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial | Litcius