Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites
Dong-Song Tian, Xiao Zhang, Russell J. Cox
Abstract
centres for bioactive fungal metabolites. Total biosynthesis usually involves fewer chemical steps and those steps move more directly to the target than comparable total chemical synthesis. However, total biosynthesis currently lacks the flexibility of chemical synthesis and the ability to easily diversify synthetic routes.
Topics & Concepts
Total synthesisBiosynthesisChemistryMetaboliteBiochemistryStereochemistryBiologyComputational biologyEnzymeMicrobial Natural Products and BiosynthesisPlant biochemistry and biosynthesisFungal Biology and Applications