Iodine-Catalyzed Aerobic Oxidation of Spirovinylcyclopropyl Oxindoles to Form Spiro-1,2-dioxolanes Diastereoselectively
Cheng Xiong, Kunpeng Cheng, Jiahua Wang, Fulai Yang, Jinrong Lu, Qingfa Zhou
Abstract
A novel method of iodine-catalyzed aerobic oxidation with spirovinylcyclopropyl oxindoles under mild conditions has been described. A series of spiro-1,2-dioxolanes were prepared in good to excellent yields and considerable diastereoselectivities. The new approach is operationally simple, scalable, and tolerant of various functional groups.
Topics & Concepts
ChemistryIodineCatalysisCombinatorial chemistryOrganic chemistryOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsAsymmetric Synthesis and Catalysis