Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4
Vijay Bhoj, Lucy Z. Li, Kalpana Parvathaneni, Zheng Zhang, Stephen Kacir, Dimitrios C. Arhontoulis, Kenneth Zhou, Bevin McGettigan-Croce, Selene Nuñez-Cruz, Gayathri Gulendran, Alina C. Boesteanu, Laura A. Johnson, Michael D. Feldman, Enrico Radaelli, Keith G. Mansfield, MacLean P. Nasrallah, Rebecca S. Goydel, Haiyong Peng, Christoph Rader, Michael C. Milone, Don L. Siegel
Abstract
, and they are able to eliminate tumors derived from the MTC TT cell line in an immunodeficient mouse xenograft model of MTC. These data demonstrate the feasibility of targeting GFRα4 by CAR T and support this antigen as a promising target for adoptive T cell immunotherapy and other antibody-based therapies for MTC.
Topics & Concepts
Chimeric antigen receptorImmunotherapyCancer researchGlial cell line-derived neurotrophic factorAntigenMedicineCD137Adoptive cell transferT cellImmunologyReceptorCD8Internal medicineImmune systemNeurotrophic factorsCAR-T cell therapy researchNanowire Synthesis and ApplicationsNeuroblastoma Research and Treatments