Chelating silica nanoparticles for efficient antibiotic delivery and particle imaging in Gram-negative bacteria
Asier R. Muguruza, Alessandro Di Maio, Nikolas J. Hodges, Jessica M. A. Blair, Zoe Pikramenou
Abstract
luminescence of the ruthenium signal. Our studies show that nanoparticles modified with aminopolycarboxylate chelating groups are an effective delivery system in bacterial growth inhibition in species whereas the molecular antibiotic is ineffective. This design provides a new platform for delivery of antibiotics that cannot alone penetrate the bacterial membrane.
Topics & Concepts
BacteriaAntibioticsDrug deliveryGram-negative bacteriaBacterial cell structureNanoparticleNanotechnologyChemistryMaterials scienceEscherichia coliBiologyBiochemistryGeneGeneticsBiosensors and Analytical DetectionAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensing