Li-Doped Ti Surface for the Improvement of Osteointegration
Longhai Qiu, Zhanbei Zhu, Feng Peng, Chi Zhang, Juning Xie, Ruixiang Zhou, Yu Zhang, Mei Li
Abstract
results of rat bone marrow mesenchymal stem cell (rBMSC) culture studies suggested that the Li-doped Ti surface significantly favored cell adhesion. Moreover, it was found that the Li-doped surface enhanced alkaline phosphatase activity and extracellular matrix mineralization of rBMSCs. In addition, the surface improved the expression of osteogenesis-related genes. Furthermore, a bone implantation model indicated that the Li-doped Ti surface showed improved osteointegration. The incorporation of Li into a Ti surface is a promising method for orthopedic applications.
Topics & Concepts
OsseointegrationMaterials sciencePlasma electrolytic oxidationBiomedical engineeringAlkaline phosphataseExtracellular matrixSurface modificationImplantChemistryElectrolyteSurgeryMedicineBiochemistryElectrodeEnzymePhysical chemistryBone Tissue Engineering MaterialsOrthopaedic implants and arthroplastyGraphene and Nanomaterials Applications