<i>Lactobacillus reuteri</i> J1 prevents obesity by altering the gut microbiota and regulating bile acid metabolism in obese mice
Chenxi Zhang, Ruxue Fang, Xingru Lu, Yu Zhang, Mo Yang, Yue Su, Yujun Jiang, Chaoxin Man
Abstract
L. reuteri J1 regulated the composition of bile acid by regulating the gut microbiome of obese mice, thus inhibiting the mechanism of the ileum FXR-FGF15 pathway and promoting the FXR-SHP pathway, and affecting the browning of WAT.
Topics & Concepts
Lactobacillus reuteriG protein-coupled bile acid receptorFarnesoid X receptorDeoxycholic acidBile acidGut floraEndocrinologyInternal medicineUrsodeoxycholic acidAkkermansia muciniphilaBiologyChemistryLactobacillusBiochemistryMedicineNuclear receptorFermentationTranscription factorGeneGut microbiota and healthDiet and metabolism studiesAdipose Tissue and Metabolism