Regulation of mTORC2 Signaling
Wenxiang Fu, Michael N. Hall
Abstract
Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.
Topics & Concepts
mTORC2mTORC1PI3K/AKT/mTOR pathwayCell biologyEffectorCell metabolismBiologyMechanistic target of rapamycinSignal transductionCellGeneticsPI3K/AKT/mTOR signaling in cancerMast cells and histaminePolyamine Metabolism and Applications