Fucoidans from <i>Cucumaria frondosa</i> ameliorate renal interstitial fibrosis <i>via</i> inhibition of the PI3K/Akt/NF-κB signaling pathway
Zhuoyue Song, Mengru Zhu, Jun Wu, Tian Yu, Yao Chen, Xianying Ye, Shijie Li, Nenggui Xu
Abstract
mechanism was also verified to inhibit the PI3K/Akt/NF-κB signaling pathway. Overall, these results showed that CFP could alleviate renal interstitial fibrosis related to the PI3K/AKT/NF-κB signaling pathway.
Topics & Concepts
PI3K/AKT/mTOR pathwayProtein kinase BSignal transductionNF-κBFibrosisChemistryCancer researchPhosphorylationInflammationCell biologyPharmacologyBiologyMedicineInternal medicineImmunologyKidney Stones and Urolithiasis TreatmentsAldose Reductase and TaurineMicrobial metabolism and enzyme function