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Involvement of CYP2E1-ROS-CD36/DGAT2 axis in the pathogenesis of VPA-induced hepatic steatosis in vivo and in vitro

Linfeng Ma, Yani Wang, Xue Chen, Limei Zhao, Yingjie Guo

2020Toxicology31 citationsDOI

Topics & Concepts

SteatosisCYP2E1CD36Oxidative stressChemistryMitochondrial ROSPharmacologyReactive oxygen speciesLiver injuryBiochemistryEndocrinologyBiologyCytochrome P450MetabolismReceptorPeroxisome Proliferator-Activated ReceptorsDrug Transport and Resistance MechanismsSphingolipid Metabolism and Signaling
Involvement of CYP2E1-ROS-CD36/DGAT2 axis in the pathogenesis of VPA-induced hepatic steatosis in vivo and in vitro | Litcius