Copper Catalyzed Oxidative Arylation of Tertiary Carbon Centers
Prakash Basnet, Melissa B. Sebold, Charles E. Hendrick, Marisa C. Kozlowski
Abstract
catalyzed oxidative arylation of a tertiary carbon-containing substrate including aryl malononitriles, 3-aryl benzofuran-2-ones, and 3-aryl oxindoles. In some cases, the nitrile groups of the aryl malononitriles undergo further reactions leading to lactones or imines. These reaction conditions are applicable for a range of arenes, including phenols, anilines, anisoles, and heteroarenes. Mechanistic studies support the formation of a cationic intermediate via a two-electron oxidation.
Topics & Concepts
ChemistryArylNitrileCatalysisCationic polymerizationOxidative phosphorylationBenzofuranPhenolsCarbon fibersSubstrate (aquarium)Organic chemistryMedicinal chemistryCombinatorial chemistryOceanographyAlkylMaterials scienceComposite materialGeologyBiochemistryComposite numberCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions