Mining proteomes for zinc finger persulfidation
Hongye Li, Andrew T. Stoltzfus, Sarah L. J. Michel
Abstract
(single-celled phytoplankton). The types of ZFs identified for each species encompassed all three common ZF ligand sets (4-cysteine, 3-cysteine-1-histidine, and 2-cysteine-2-hisitidine), indicating that persulfidation of ZFs is broad. Overlap analysis between different species identified several common ZFs. GO and KEGG analysis identified pathway enrichment for ubiquitin-dependent protein catabolic process and viral carcinogenesis. These collective findings support ZF persulfidation as a wide-ranging PTM that impacts all classes of ZFs.
Topics & Concepts
Zinc fingerProteomeComputational biologyProteomicsZincBioinformaticsBiologyComputer scienceChemistryGeneticsGeneTranscription factorOrganic chemistrySulfur Compounds in BiologyRedox biology and oxidative stressFolate and B Vitamins Research