How Monoamine Oxidase A Decomposes Serotonin: An Empirical Valence Bond Simulation of the Reactive Step
Alja Prah, Miha Purg, Jernej Stare, Robert Vianello, Janez Mavri
Abstract
, which provides strong evidence for the validity of the proposed hydride-transfer mechanism. Together with additional experimental and computational work, the results presented herein contribute to a deeper understanding of the catalytic mechanism of MAO A and flavoenzymes in general, and in the long run, they should pave the way toward applications in neuropsychiatry.
Topics & Concepts
Flavin groupChemistryMonoamine oxidaseMonoamine neurotransmitterValence bond theoryMonoamine oxidase AComputational chemistrySerotoninHydrideMonoamine oxidase BEnzymeStereochemistryMolecular orbitalOrganic chemistryBiochemistryMoleculeReceptorHydrogenMicrobial metabolism and enzyme functionBiochemical Acid Research StudiesCyclopropane Reaction Mechanisms