Citric acid cross-linking of a hydrogel from <i>Aloe vera</i> (<i>Aloe barbadensis</i> M.) engenders a pH-responsive, superporous, and smart material for drug delivery
Jaffar Irfan, Arshad Ali, Muhammad Ajaz Hussain, Muhammad Tahir Haseeb, Muhammad Naeem‐ul‐Hassan, Syed Zajif Hussain
Abstract
fate of the tablet formulation was observed through an X-ray study. The CL-ALH-based tablet safely passed through the stomach of a stray dog without any significant erosion and then disintegrated in the small intestine and colon. These findings confirmed that the CL-ALH is an effective excipient for designing a sustained-release drug delivery system for the small intestine and colon.
Topics & Concepts
Aloe veraChemistrySwellingCitric acidKineticsNuclear chemistryDehydrationChemical engineeringBiochemistryQuantum mechanicsBotanyEngineeringBiologyPhysicsPhytochemistry and biological activity of medicinal plantsAdvancements in Transdermal Drug DeliveryMicrofluidic and Capillary Electrophoresis Applications