Ethosomal gel for rectal transmucosal delivery of domperidone: design of experiment, <i>in vitro,</i> and <i>in vivo</i> evaluation
Wedad Sakran, Rania S. Abdel-Rashid, Fatma Saleh, Raghda Abdel-monem
Abstract
of DOM by twofolds compared to free DOM gel. The study suggested that ethosomes incorporated in gels could be an efficient candidate for rectal transmucosal delivery of DOM.
Topics & Concepts
MucoadhesionPermeationIn vivoEx vivoFactorial experimentZeta potentialBioavailabilityBioadhesiveChromatographyDrug deliveryMaterials sciencePharmacologyChemistryMedicineMembraneNanoparticleNanotechnologyBiologyBiotechnologyStatisticsMathematicsBiochemistryNausea and vomiting managementAnesthesia and Pain ManagementAdvanced Drug Delivery Systems