A novel variant of VEGFR2 identified by a pan-cancer screening of recurrent somatic mutations in the catalytic domain of tyrosine kinase receptors enhances tumor growth and metastasis
Elisabetta Grillo, Michela Corsini, Cosetta Ravelli, Margherita Di Somma, Luca Zammataro, Eugenio Monti, Marco Presta, Stefania Mitola
Topics & Concepts
Cancer researchBiologyReceptor tyrosine kinaseMetastasisProtein kinase domainTyrosine kinaseContext (archaeology)MutationCancerSomatic cellSignal transductionGeneGeneticsPaleontologyMutantPI3K/AKT/mTOR signaling in cancerHER2/EGFR in Cancer ResearchAngiogenesis and VEGF in Cancer