Mitochondrial Metabolism Regulation of T Cell–Mediated Immunity
Elizabeth M. Steinert, Karthik Vasan, Navdeep S. Chandel
Abstract
Recent evidence supports the notion that mitochondrial metabolism is necessary for T cell activation, proliferation, and function. Mitochondrial metabolism supports T cell anabolism by providing key metabolites for macromolecule synthesis and generating metabolites for T cell function. In this review, we focus on how mitochondrial metabolism controls conventional and regulatory T cell fates and function.
Topics & Concepts
BiologyCell metabolismAnabolismFunction (biology)Cell biologyMetabolismMitochondrionT cellCellCell functionImmune systemBiochemistryImmunologyImmune cells in cancerImmune Cell Function and InteractionCancer, Hypoxia, and Metabolism