Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, <i>in vivo</i> and <i>in silico</i> studies
Heba A. Elsebaie, Mohamed S. Nafie, Haytham O. Tawfik, Amany Belal, Mohammed M. Ghoneim, Ahmad J. Obaidullah, Salwa Shaaban, Abdelmoneim A. Ayed, Mohamed El‐Naggar, Ahmed B. M. Mehany, Moataz A. Shaldam
Abstract
study illustrated the anticancer activity of compound 2n by reduction of tumor mass and volume, and the tumor inhibition ratio reached 56.1% with an improvement of hematological parameters. Accordingly, compound 2n can be further developed as a selective target-oriented chemotherapeutic against breast cancer.
Topics & Concepts
PyridineApoptosisIn silicoArylChemistryIn vivoPharmacologyDerivative (finance)InducerCombinatorial chemistryStereochemistryMedicinal chemistryBiochemistryMedicineBiologyOrganic chemistryEconomicsFinancial economicsGeneBiotechnologyAlkylCancer Mechanisms and TherapySynthesis and biological activityCytokine Signaling Pathways and Interactions