HLA Allele–Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction

Kanoot Jaruthamsophon, Paul Thomson, Chonlaphat Sukasem, Dean J. Naisbitt, Munir Pirmohamed

2021The Annual Review of Pharmacology and Toxicology33 citationsDOI

Abstract

Human leukocyte antigen (HLA) is a hallmark genetic marker for the prediction of certain immune-mediated adverse drug reactions (ADRs). Numerous basic and clinical research studies have provided the evidence base to push forward the clinical implementation of HLA testing for the prevention of such ADRs in susceptible patients. This review explores current translational progress in using HLA as a key susceptibility factor for immune ADRs and highlights gaps in our knowledge. Furthermore, relevant findings of HLA-mediated drug-specific T cell activation are covered, focusing on cellular approaches to link genetic associations to drug-HLA binding as a complementary approach to understand disease pathogenesis.

Topics & Concepts

Human leukocyte antigenDrug reactionAlleleImmunologyDiseaseDrugImmune systemMedicineAdverse drug reactionPathogenesisBioinformaticsBiologyAntigenGeneticsGenePharmacologyInternal medicineDrug-Induced Adverse ReactionsBiosimilars and Bioanalytical MethodsPharmacovigilance and Adverse Drug Reactions