Nationwide Implementation of Essential Pharmacogenomic Testing in the Netherlands: A Decision-Analytic Model of Lives Saved and Cost-Effectiveness
Salman Raza, Abdullah Khan, Faisal Mehmood, Umar Farooq
2025Specialty journal of Pharmacognosy Phytochemistry and Biotechnology43 citationsDOIOpen Access PDF
Abstract
Evidence from forward-looking clinical investigations indicates that using pharmacogenomics (PGx) to guide therapy decisions can lower the occurrence of serious and life-threatening drug complications. The Dutch Pharmacogenetics Working Group (DPWG) designates certain drug–gene interaction (DGI) scenarios that can avert drug-associated mortality as “essential,” yet their combined clinical and economic value has not been fully quantified. This study aims to evaluate the national-level impact and
Topics & Concepts
PharmacogenomicsMedicinePharmacogeneticsIntensive care medicineRisk analysis (engineering)Value (mathematics)MEDLINEPharmacotherapyGenetic testingClinical trialDrug responseDrugDrug developmentActuarial scienceRisk assessmentPharmacogenetics and Drug MetabolismEthics in Clinical ResearchGenetic Associations and Epidemiology