ERK1/2-dependent BDNF synthesis and signaling is required for the antidepressant effect of microglia stimulation
Xu Lu, Huijun Liu, Zixuan Cai, Zhichao Hu, Minxiu Ye, Yue Gu, Yue Wang, Dan Wang, Qun Lu, Zhongxia Shen, Xinhua Shen, Chao Huang
Topics & Concepts
Tropomyosin receptor kinase BBrain-derived neurotrophic factorNeurotrophic factorsMicrogliaStimulationAntidepressantDentate gyrusEndocrinologyPI3K/AKT/mTOR pathwayProtein kinase BSignal transductionChemistryPharmacologyInternal medicineBiologyReceptorCell biologyHippocampusMedicineInflammationNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersNerve injury and regeneration