A dendritic cell-like biomimetic nanoparticle enhances T cell activation for breast cancer immunotherapy
Yanhua Li, Kun Tang, Xia Zhang, Wei Pan, Na Li, Bo Tang
Abstract
@HA can effectively activate T cells and improve their immune response to significantly inhibit the growth of breast cancer. Moreover, it also proved that T cell activation combining immune checkpoint blocking induced the "1 + 1 >2" immunotherapy effect against immunosuppressive tumors. We expect that this strategy will provide new insights into tumor immunotherapy by modulating T cell behavior.
Topics & Concepts
Dendritic cellImmunotherapyCancer immunotherapyBreast cancerCellCancer researchNanoparticleCancerChemistryNanotechnologyImmune systemMedicineMaterials scienceImmunologyInternal medicineBiochemistryImmunotherapy and Immune ResponsesCAR-T cell therapy researchCancer Immunotherapy and Biomarkers