Radiation-induced small extracellular vesicles as “carriages” promote tumor antigen release and trigger antitumor immunity
Wanzun Lin, Yanyan Xu, Xiaochuan Chen, Jun Liu, Youliang Weng, Qingyang Zhuang, Feifei Lin, Zongwei Huang, Shihong Wu, Jianming Ding, Long Chen, Xianxin Qiu, Lurong Zhang, Junxin Wu, Duo Lin, Sufang Qiu
Abstract
: Our results demonstrate that the use of sEVs secreted by irradiated tumor cells constitutes an efficient approach for tumor antigen delivery and presentation and highlight the role of sEVs in radiation-triggered antitumor immunity.
Topics & Concepts
Extracellular vesiclesImmunityAntigenExtracellularChemistryVesicleCell biologyImmune systemCancer researchImmunologyBiologyBiochemistryMembraneExtracellular vesicles in diseaseNanoplatforms for cancer theranosticsMicroRNA in disease regulation