Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes
Mohammed T.-E. Maghraby, Ola M. F. Abou‐Ghadir, Samia G. Abdel‐Moty, Asmaa Y. Ali, Ola I. A. Salem
Topics & Concepts
ChemistryThiazoleBenzimidazoleCyclooxygenaseIn vivoIC50StereochemistryArachidonate 5-lipoxygenaseEnzymePharmacologyBiochemistryIn vitroArachidonic acidOrganic chemistryBiotechnologyMedicineBiologyInflammatory mediators and NSAID effectsSynthesis and biological activityBioactive Compounds and Antitumor Agents