Integrative Analysis Identified CD38 As a Key Node That Correlates Highly with Immunophenotype, Chemoradiotherapy Resistance, And Prognosis of Head and Neck Cancer
Zhengxi He, Chunxue Yue, Xiuwen Chen, Xin Li, Li Zhang, Shan Tan, Xia Yi, Gengqiu Luo, Yanhong Zhou
Abstract
is a key gene involved in radiotherapy, chemotherapy, and immune drug resistance in HNC. This study provides a reliable biomarker to predict the prognosis of patients with HNC and a reference for clinical comprehensive treatment of HNC. Individualization combined with CD38 monoclonal antibodies might provide a promising treatment strategy for this fatal disease, and this comprehensive treatment might reduce the damage to normal tissue and improve the prognosis and quality of life of patients with HNC.
Topics & Concepts
MedicineHead and neck cancerRadiation therapyOncologyImmunotherapyHead and neck squamous-cell carcinomaChemoradiotherapyCancerChemotherapyInternal medicineCancer researchCalcium signaling and nucleotide metabolismPeptidase Inhibition and AnalysisLung Cancer Research Studies