Structural characterization of a polysaccharide from <i>Abelmoschus esculentus</i> L. Moench (okra) and its hypoglycemic effect and mechanism on type 2 diabetes mellitus
Xue-Qing Geng, Lichao Pan, Hui-Qing Sun, Yuanyuan Ren, Zhen‐Yuan Zhu
Abstract
in a molar ratio of 2.42 : 3.36 : 6.46 : 13.31 : 3.12 : 1, respectively. The hypoglycemic effect and mechanism of AeP-P-1 on type 2 diabetes mellitus were also explored. Firstly, AeP-P-1 can reduce blood lipids and liver and kidney damage caused by T2DM. Finally, AeP-P-1 induces the phosphorylation of GSK3β, maintains the activity of glycogen synthase (GCS), and promotes glycogen synthesis by regulating the expression of insulin/PI3K/Akt pathway proteins. These results indicated that AeP-P-1 could be developed as a potential ingredient in immunostimulatory agents.
Topics & Concepts
AbelmoschusType 2 Diabetes MellitusMechanism (biology)PolysaccharideDiabetes mellitusCharacterization (materials science)Internal medicineChemistryMedicineEndocrinologyBiochemistryBiologyHorticultureMaterials scienceNanotechnologyPhysicsQuantum mechanicsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell WallsNatural Antidiabetic Agents Studies