COVID19- clinical presentation and therapeutic considerations
Grace Kenny, Patrick Mallon
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a pandemic infection in 2020 has presented many therapeutic challenges. Not least among these is the importance of abnormal host response to infection that is one of the main drivers of more severe disease. Despite significant research endeavours, very few effective therapies have been identified, in part related to the different pathogenic mechanisms underlying different stages of clinical COVID-19. This mini review summarises data related to current and potential future therapies for COVID-19 and highlights the many challenges inherent in developing effective therapeutic options for new pandemic infection.
Topics & Concepts
PandemicCoronavirus disease 2019 (COVID-19)Intensive care medicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Medicine2019-20 coronavirus outbreakDiseaseCoronavirusHost responsePresentation (obstetrics)Therapeutic approachImmunologyInfectious disease (medical specialty)VirologyPathologyImmune systemRadiologyOutbreakCOVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19