Exploring the therapeutic mechanisms of Gleditsiae Spina acting on pancreatic cancer<i>via</i>network pharmacology, molecular docking and molecular dynamics simulation
Hongtao Duan, Rui Zhang, Lu Yuan, Yiyuan Liu, Aiminuer Asikaer, Yang Liu, Yan Shen
Abstract
, respectively). Collectively, our findings identify active components and potential targets in Gleditsiae Spina for the treatment of pancreatic cancer, which may help to explore leading compounds and potential drugs for pancreatic cancer.
Topics & Concepts
Pancreatic cancerCancer researchSignal transductionPharmacologyChemistryKaempferolMAPK/ERK pathwayKinaseTumor necrosis factor alphaVascular endothelial growth factorBiologyBiochemistryCancerMedicineQuercetinImmunologyInternal medicineVEGF receptorsAntioxidantComputational Drug Discovery MethodsSynthesis and biological activityCholinesterase and Neurodegenerative Diseases