Synthesis of a sacubitril precursor <i>via</i> the construction of one-pot chemoenzymatic cascades
Long Chen, Ge Qu, Zhiqiang Cai, Bo Yuan, Zhoutong Sun
Abstract
A key precursor of sacubitril was synthesized with excellent diastereoselectivity via the construction of three one-pot enzymatic cascades.
Topics & Concepts
CatalysisChemistryCombinatorial chemistryOrganic chemistryChemistry and Chemical EngineeringComputational Drug Discovery MethodsVarious Chemistry Research Topics