Uromodulin, Salt, and 24-Hour Blood Pressure in the General Population
Belén Ponte, Menno Pruijm, Daniel Ackermann, Eric Olinger, Sonia Youhanna, Bruno Vogt, Michel Burnier, Antoinette Péchère-Bertschi, Murielle Bochud, Olivier Devuyst
Abstract
Uromodulin is a key protein involved in the risk of CKD and hypertension, essentially produced by the cells lining the thick ascending limb of the loop of Henle ([1][1]). Uromodulin regulates sodium and potassium transport activity in the thick ascending limb, and its deletion in mice leads to salt
Topics & Concepts
Tamm–Horsfall proteinMedicineLoop of HenleSodiumPotassiumBlood pressurePopulationInternal medicineEndocrinologyAnatomyKidneyChemistryOrganic chemistryReabsorptionEnvironmental healthDiet and metabolism studiesBirth, Development, and HealthIon Transport and Channel Regulation