Mitochondria-targeted polydopamine nanoprobes for visualizing endogenous sulfur dioxide derivatives in a rat epilepsy model
Qiaoqiao Ci, Xiaofei Qin, Jinhua Liu, Rui Wang, Zheng Li, Wenjing Qin, Kah‐Leong Lim, Chengwu Zhang, Lin Li
Abstract
The authors designed and synthesized a mitochondria-targeted polydopamine nanoprobe for visualizing endogenous SO<sub>3</sub><sup>2−</sup>/HSO<sub>3</sub><sup>−</sup> by the nucleophilic addition reaction. The nanoprobe was used for imaging SO<sub>2</sub> derivatives both in the mitochondria of cells, zebrafish, and hippocampus of a rat model of epilepsy.
Topics & Concepts
NanoprobeMitochondrionEndogenyNucleophileChemistryZebrafishBiophysicsCombinatorial chemistryNanotechnologyBiochemistryMaterials scienceBiologyNanoparticleCatalysisGeneSulfur Compounds in BiologyMolecular Sensors and Ion DetectionAdvanced biosensing and bioanalysis techniques