Nicotine, smoking, podocytes, and diabetic nephropathy
Edgar A. Jaimes, Ming-Sheng Zhou, Mohammed Siddiqui, Gabriel Rezonzew, Runxia Tian, Surya V. Seshan, Alecia N. Muwonge, Nicholas J. Wong, Evren U. Azeloglu, Alessia Fornoni, Sandra Merscher, Leopoldo Raij
Abstract
In this study, we demonstrate that nicotine increases the production of reactive oxygen species, increases cyclooxygenase-2 expression, and upregulates Cd36 while inducing downregulation of AMP-activated protein kinase. In vivo nicotine increases proteinuria and fibronectin expression in diabetic mice. This study demonstrates that effects of nicotine on podocytes are responsible, at least in part, for the deleterious effects of smoking in the progression of chronic kidney disease, including diabetic nephropathy.
Topics & Concepts
Diabetic nephropathyNicotineDownregulation and upregulationProteinuriaPodocyteMedicineInternal medicineEndocrinologyCD36Kidney diseaseDiabetes mellitusReactive oxygen speciesIn vivoKidneyBiologyCell biologyReceptorBiochemistryGeneBiotechnologyRenal Diseases and GlomerulopathiesCircadian rhythm and melatoninDiet, Metabolism, and Disease