NHC-catalyzed [12+2] reaction of polycyclic arylaldehydes for access to indole derivatives
Hong Ji, Juan Zou, Chengli Mou, Yonggui Liu, Shi‐Chao Ren, Yonggui Robin
Abstract
NHC-catalyzed remote activation of C(sp 3 )–H and asymmetric [12+2] cycloaddition reaction for access to structurally complex bioactive indole derivatives.
Topics & Concepts
ChemistryIndole testCarbeneCatalysisMoietyCycloadditionCombinatorial chemistryMorpholineMedicinal chemistryStereochemistryOrganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods