Engagement of an optimized lentiviral vector enhances the expression and cytotoxicity of CAR in human NK cells
Changjiang Guo, Han Chen, Jie Yu, Hui Lü, Qing Xia, Xiaojuan Li, Xiali Guo, Tong Wang, Lingtong Zhi, Zhiyuan Niu, Wuling Zhu
Topics & Concepts
Chimeric antigen receptorCytotoxicityNKG2DHEK 293 cellsPuromycinReporter geneK562 cellsGreen fluorescent proteinInterleukin 12Cell biologyMolecular biologyBiologyCancer researchIn vitroChemistryCell cultureCytotoxic T cellGene expressionImmunologyGeneT cellImmune systemGeneticsProtein biosynthesisCAR-T cell therapy researchImmune Cell Function and InteractionVirus-based gene therapy research