Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination
Heather N. Grome, Michael G. Threlkeld, Steve Threlkeld, Charles Newman, Roosecelis B. Martines, Sarah Reagan-Steiner, Michael A. Whitt, Maria Gomes‐Solecki, Nisha Nair, Mary‐Margaret A. Fill, Timothy F. Jones, William Schaffner, John Dunn
Abstract
A multisystem infl ammatory syndrome in chil- dren (MIS-C) and adults (MIS-A) occurring after coronavirus disease (COVID-19) has been identifi ed; onset is 4-6 weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (1-3). A case defi nition for MIS-A has been developed by the Centers for Disease Control and Prevention (CDC) (4); MIS-A after vaccination is rare and remains of great clinical and public health interest (5). We report a case study and histopathologic fi ndings from a fatal MIS-A case after SARS-CoV-2 infection and subsequent complete COVID-19 vaccination.