AAV6 Vexosomes Mediate Robust Suicide Gene Delivery in a Murine Model of Hepatocellular Carcinoma
Nusrat Khan, Shubham Maurya, Sridhar Bammidi, Giridhara R. Jayandharan
Abstract
vexosomes and AP20187 in a murine xenograft model revealed a 2.3-fold increase in tumor regression in comparison to untreated animals. These findings were further corroborated by histological analysis and apoptosis assays. In conclusion, our data demonstrate the therapeutic potential of AAV6 vexosomes in a xenotransplantation model of HCC. Furthermore, the simplicity in production and isolation of vexosomes should further facilitate its application in other malignancies.
Topics & Concepts
Suicide geneGenetic enhancementIn vivoHepatocellular carcinomaCancer researchCytotoxic T cellMicrovesiclesXenotransplantationGene deliveryApoptosisIn vitroCell cultureBiologyImmunologymicroRNAGeneMedicineTransplantationInternal medicineGeneticsVirus-based gene therapy researchRNA Interference and Gene DeliveryAnimal Virus Infections Studies