Performance of Immunoglobulin G Serology on Finger Prick Capillary Dried Blood Spot Samples to Detect a SARS-CoV-2 Antibody Response
Aidan M. Nikiforuk, Brynn McMillan, Sofia Bartlett, Ana Márquez, Tamara Pidduck, Jesse Kustra, David A. Goldfarb, Vilte Barakauskas, Graham Sinclair, David M. Patrick, Manish Sadarangani, Gina Ogilvie, Mel Krajden, Muhammad Morshed, Inna Sekirov, Agatha N. Jassem
Abstract
Dried blood spot samples have comparable diagnostic accuracy to serum collected by venipuncture when tested by an electrochemiluminescent assay for antibodies and should be considered to reliably detect seropositivity following SARS-CoV-2 infection and/or vaccination.
Topics & Concepts
Dried blood spotMedicineSerologyReceiver operating characteristicConfidence intervalSeroconversionLogistic regressionArea under the curvePopulationAntibodyImmunologyInternal medicineVaccinationMultiplexBiologyEnvironmental healthGeneticsBioinformaticsSARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingCOVID-19 Clinical Research Studies