High frequency of central nervous system involvement in transformed Waldenström macroglobulinemia
Éric Durot, Lukshe Kanagaratnam, Saurabh Zanwar, Elise Toussaint, Efstathios Kastritis, Shirley D’Sa, Miguel Alcoceba, Cécile Tomowiak, Bénédicte Hivert, Caroline Protin, Jithma P. Abeykoon, Josephine M. I. Vos, Anne‐Sophie Michallet, Cyrielle Rodier, Jehan Dupuis, Stéphane Leprêtre, Fatiha Merabet, Xavier Roussel, Jean‐Marc Zini, Caroline Régny, Aisha S Patel, Pierre Morel, Damien Roos‐Weil, Steven P. Treon, Meletios Α. Dimopoulos, Ramón García‐Sánz, Prashant Kapoor, Jorge J. Castillo, Alain Delmer
Abstract
Histologicaltransformation (HT) to diffuse large B-cell lymphoma (DLBCL) is a rare event in Waldenström macroglobulinemia (WM) and is associated with a poor prognosis.1-4 It confers an inferior outcome compared with WM patients without HT.2,3 Most transformed WM patients present with elevated serum lactate dehydrogenase (LDH) levels and extranodal disease.1 Among extranodal sites, the central nervous system (CNS) is one of the most frequently involved sites identified at diagnosis of transformed WM (ranging from 13% to 18%).1,3 However, the prognostic value of CNS involvement is unknown, and the rate of CNS involvement at relapse has not been previously reported in this setting.