Mild and efficient ammonium chloride catalyzed Greener synthesis of tetrahydro-β-carboline
Milind V. Gaikwad, Sunil Gaikwad, Rahul D. Kamble
Abstract
This protocol involves the NH4Cl catalyzed Pictet−Spengler reactions of tryptamine and arylaldehydes in anhydrous MeOH solvent to gives corresponding tetrahydro-β-carbolines (THβC) with 90% yield. This methodology offers mild, efficient and green reagent towards the synthesis THβC with tolerance of wide functional group. This is the first report of Pictet–Spengler reaction using mild NH4Cl in MeOH solvent.
Topics & Concepts
AnhydrousTryptamineReagentYield (engineering)ChemistryCatalysisSolventAmmonium chlorideOrganic chemistryChlorideCombinatorial chemistryMaterials scienceBiochemistryMetallurgySynthesis and bioactivity of alkaloidsMulticomponent Synthesis of HeterocyclesSynthesis and Biological Evaluation