Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation
Ta‐Chiang Liu, Justin Kern, Umang Jain, Naomi Sonnek, Shanshan Xiong, Katherine F. Simpson, Kelli L. VanDussen, Emma S. Winkler, Talin Haritunians, Atika Malique, Qiuhe Lu, Yo Sasaki, Chad Storer, Michael Diamond, Richard D. Head, Dermot McGovern, Thaddeus S. Stappenbeck
Topics & Concepts
Paneth cellBiologyFarnesoid X receptorDeoxycholic acidInnate immune systemG protein-coupled bile acid receptorBile acidCellCell biologyReceptorMicrobiomeImmunityImmunologyInterferonSignal transductionCancer researchEndocrinologyImmune systemBiochemistryNuclear receptorBioinformaticsTranscription factorGeneSmall intestineGut microbiota and healthIL-33, ST2, and ILC PathwaysInflammatory Bowel Disease