Selective radical cascade (4+2) annulation with olefins towards the synthesis of chroman derivatives <i>via</i> organo-photoredox catalysis
Zhipeng Guan, Xingxing Zhong, Yayu Ye, Xiangwei Li, Hengjiang Cong, Hong Yi, Heng Zhang, Zhiliang Huang, Aiwen Lei
Abstract
We have developed a (4 + 2) radical annulation approach for the synthesis of diverse chromans. This method is complementary to the traditional Diels–Alder [4 + 2] annulation of ortho -quinone methides and electron-rich dienophiles.
Topics & Concepts
AnnulationChemistryCascadePhotoredox catalysisCatalysisCombinatorial chemistryOrganic chemistryPhotocatalysisChromatographySynthesis of Indole DerivativesSulfur-Based Synthesis TechniquesRadical Photochemical Reactions