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Optimization of pyrazole/1,2,4-triazole as dual EGFR/COX-2 inhibitors: Design, synthesis, anticancer potential, apoptosis induction and cell cycle analysis

Nesma M. Kahk, Fatma El Zahraa Ammar Mohamed, Marwa M. Abdelhakeem, Rania B. Bakr

2025European Journal of Medicinal Chemistry19 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryPyrazoleApoptosisTriazoleCell cycleDual (grammatical number)Cell cycle checkpointCombinatorial chemistryStereochemistryCancer researchBiochemistryOrganic chemistryBiologyArtLiteratureSynthesis and biological activityComputational Drug Discovery MethodsClick Chemistry and Applications
Optimization of pyrazole/1,2,4-triazole as dual EGFR/COX-2 inhibitors: Design, synthesis, anticancer potential, apoptosis induction and cell cycle analysis | Litcius