Oxidative stress induced by realgar in neurons: p38 MAPK and ERK1/2 perturb autophagy and induce the p62-Keap1-Nrf2 feedback loop to activate the Nrf2 signalling pathway
Meng Yuan, Rui Feng, Zhao Yang, Tingting Liu, Taoguang Huo, Hong Jiang
Topics & Concepts
AutophagyRealgarNeurotoxicityKEAP1MAPK/ERK pathwayp38 mitogen-activated protein kinasesCell biologyPI3K/AKT/mTOR pathwayOxidative stressPharmacologyProgrammed cell deathSignal transductionChemistryBiologyApoptosisToxicityBiochemistryTranscription factorMineralogyOrganic chemistryGeneGenomics, phytochemicals, and oxidative stressArsenic contamination and mitigationAntioxidants, Aging, Portulaca oleracea