Artificial intelligence for the detection of age-related macular degeneration in color fundus photographs: A systematic review and meta-analysis
Li Dong, Qiong Yang, Ruiheng Zhang, Wen Bin Wei
Abstract
BACKGROUND: Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly population. The application of artificial intelligence (AI) provides convenience for the diagnosis of AMD. This systematic review and meta-analysis aimed to quantify the performance of AI in detecting AMD in fundus photographs. METHODS: We searched PubMed, Embase, Web of Science and the Cochrane Library before December 31st, 2020 for studies reporting the application of AI in detecting AMD in color fundus photographs. Then, we pooled the data for analysis. PROSPERO registration number: CRD42020197532. FINDINGS: = 0.030), which was the main cause for the heterogeneity. For studies applying convolutional neural networks in the Age-Related Eye Disease Study database, the pooled AUROC, sensitivity, specificity, and DOR were 0.983 (95% CI:0.978-0.988), 0.88 (95% CI:0.88-0.88), 0.91 (95% CI:0.91-0.91), and 273.14 (95% CI:130.79-570.43), respectively. INTERPRETATION: Our data indicated that AI was able to detect AMD in color fundus photographs. The application of AI-based automatic tools is beneficial for the diagnosis of AMD. FUNDING: Capital Health Research and Development of Special (2020-1-2052).