LncRNA DSCAM-AS1 promotes colorectal cancer progression by acting as a molecular sponge of miR-384 to modulate AKT3 expression
Bo Li, Hai Sun, Jiayu Zhang
Abstract
. MicroRNA-384(miR-384) was directly targeted by DSCAM-AS1 in CRC cells, and repression of DSCAM-AS1 inhibited the expression of AKT3, a known target of miR-384 in CRC. In addition, repression of miR-384 or overexpression of AKT3 could partially rescue the inhibitory effect of DSCAM-AS1 knockdown on CRC progression. In summary, DSCAM-AS1 exerted an oncogenic role in CRC by functioning as a competing endogenous RNA of miR-384 to bring about regulation of AKT3 expression. These results implied that DSCAM-AS1 might be a novel therapeutic target for patients suffering from CRC.
Topics & Concepts
Gene knockdownBiologyCancer researchmicroRNADownregulation and upregulationLong non-coding RNATumor progressionColorectal cancerCell growthCancerCell cultureGeneGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCircular RNAs in diseases