Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis
Jingyi Li, Chunfen Mo, Yifan Guo, Bowen Zhang, Xiao Feng, Qiuyue Si, Xiaobo Wu, Zhe Zhao, Lixin Gong, Dan He, Jichun Shao
Abstract
Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
Topics & Concepts
PIN1PathogenesisProlyl isomeraseIsomeraseDiseasePeptidylprolyl isomeraseMedicineCancer researchChemistryComputational biologyBiologyImmunologyBiochemistryInternal medicineEnzymeSignaling Pathways in DiseaseToxin Mechanisms and ImmunotoxinsPeptidase Inhibition and Analysis