Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint
Etienne Masle‐Farquhar, Timothy J. Peters, Lisa A. Miosge, Ian A. Parish, Christoph Weigel, Christopher C. Oakes, Joanne H. Reed, Christopher C. Goodnow
Abstract
B cell formation, and inform how NFATC1 or EGR2 mutations promote B1 cell-derived chronic lymphocytic leukemias.
Topics & Concepts
BiologyB cellDownregulation and upregulationTranscription factorNFATCancer researchCellCell biologyGeneImmunologyGeneticsAntibodyImmune Cell Function and InteractionT-cell and B-cell ImmunologyChronic Lymphocytic Leukemia Research