The role of gonadal hormones in regulating opioid antinociception
Qi Xu, Lin Jin, Luyang Wang, Yingying Tang, Hui Wu, Qing Chen, Lihong Sun
Abstract
Opioids are the most prescribed drugs for the alleviation of pain. Both clinical and preclinical studies have reported strong evidence for sex-related divergence regarding opioid analgesia. There is an increasing amount of evidence indicating that gonadal hormones regulate the analgesic efficacy of opioids. This review presents an overview of the importance of gonadal steroids in modulating opioid analgesic responsiveness and focuses on elaborating what is currently known regarding the underlyingmechanism. We sought to identify the link between gonadal hormones and the effect of oipiod antinociception.
Topics & Concepts
OpioidHormoneGonadal hormonesPharmacologyEndocrinologyInternal medicineMedicineReceptorCastrationPain Mechanisms and TreatmentsHormonal and reproductive studiesPediatric Pain Management Techniques